Samantha Womack, 2 Kasım 1972'de Brighton, East Sussex, İngiltere, Birleşik Krallık'ta doğdu. Çocukluktan beri tiyatro ve dansla ilgilenen Womack, oyunculuk kariyerine 1989'da başladığı "Doctor Who" adlı televizyon dizisiyle başladı. Daha sonra çeşitli televizyon dizilerinde ve filmlerde rol aldı.

Womack, particularly notable for her role in the British soap opera "EastEnders" from 2010 to 2016, where she played the character Ronnie Mitchell. She also appeared in the West End production of the musical "Chicago" and had a notable role in the film "The Kingsman: The Golden Circle". Her latest project is the upcoming film "The Silent Twins".

Womack has been nominated for several awards throughout her career, including the British Soap Award for Best Actress.